I'm not talking insane compression, here. More like the type you get out of your standard superstock 1000cc-1400cc bike. You can run an easy 8-10ftlbs of boost out of a stock Busa motor and get hp figures in the 240 area pretty easy without burning up to motor. But in a V-Twin application, running 7-9ftlbs of boost will trigger a torque curve that should stay above 100ftlbs from about 2500rpm (or so) to 6000rpm, usually peaking in the 130 range in or around the 4500rpm range.
I've seen v-twins running flat-top weisco pistions with 8.5to1 and get solid 150hp ranges all day and night. I know a Busa owner that does his own mapping with a stock motor hit the 260 range. He's never dropped a piston and as far as I know only runs premium 93 octane pump gas. I'm not expert, either, but If you run FI motors and have a laptop you may be in pretty good shape if you know fuelling. I don't. I'm just giving my take from what I've experienced. Personally, I'd go blower. Much more consistant air pressure in application.